The study of Mu DNA transposition in vitro has resulted in a much better understanding of the biochemical details of the transposition process. An early step in transposition is the generation of a 5th structure which is the product of the strand‐tansfer reaction. The polarity of the strand transfer has been determined and substantial progress has been made on the role of the individual proteins. Moreover, the strand‐transfer reaction is mediated by stable protein–DNA complexes, or transposomes, and the reaction can (...) be divided into two sequential steps. The role of the transposomes and the requirement for a supercoiled Mu DNA substrate are also discussed. (shrink)

This article defends the Fixed Point Thesis: that it is always a rational mistake to have false beliefs about the requirements of rationality. The Fixed Point Thesis is inspired by logical omniscience requirements in formal epistemology. It argues to the Fixed Point Thesis from the Akratic Principle: that rationality forbids having an attitude while believing that attitude is rationally forbidden. It then draws out surprising consequences of the Fixed Point Thesis, for instance that certain kinds of a priori justification are (...) indefeasible and that misleading all-things-considered evidence about rational requirements is impossible. Finally, the Fixed Point Thesis is applied to defend the Right Reasons position on peer disagreement, according to which an agent who has drawn the correct conclusion from her evidence should retain belief in that conclusion even in the face of disagreeing peers. (shrink)

'Fundamentals of Bayesian Epistemology' provides an accessible introduction to the key concepts and principles of the Bayesian formalism. This volume introduces degrees of belief as a concept in epistemology and the rules for updating degrees of belief derived from Bayesian principles.--.

'Fundamentals of Bayesian Epistemology' provides an accessible introduction to the key concepts and principles of the Bayesian formalism. Volume 2 introduces applications of Bayesianism to confirmation and decision theory, then gives a critical survey of arguments for and challenges to Bayesian epistemology.--.

Michael G. Titelbaum presents a new Bayesian framework for modeling rational degrees of belief—the first of its kind to represent rational requirements on agents who undergo certainty loss.

A common objection to sense-datum theories of perception is that they cannot give an adequate account of the fact that introspection indicates that our sensory experiences are directed on, or are about, the mind-independent entities in the world around us, that our sense experience is transparent to the world. In this paper I point out that the main force of this claim is to point out an explanatory challenge to sense-datum theories.

The disjunctive theory of perception claims that we should understand statements about how things appear to a perceiver to be equivalent to statements of a disjunction that either one is perceiving such and such or one is suffering an illusion (or hallucination); and that such statements are not to be viewed as introducing a report of a distinctive mental event or state common to these various disjoint situations. When Michael Hinton first introduced the idea, he suggested that the burden (...) of proof or disproof lay with his opponent, that what was needed was to show that our talk of how things look or appear to one.. (shrink)

Recent discussion of Vogel-style “bootstrapping” scenarios suggests that they provide counterexamples to a wide variety of epistemological theories. Yet it remains unclear why it’s bad for a theory to permit bootstrapping, or even exactly what counts as a bootstrapping case. Going back to Vogel's original bootstrapping example, I note that an agent who could gain justification through the method Vogel describes would have available a “no-lose investigation”: an investigation that can justify a proposition but has no possibility of undermining it. (...) The main suggestion of this article is that an epistemological theory should not permit no-lose investigations. I identify necessary and sufficient conditions for such investigations, then explore epistemological theories that rule them out. If we want to avoid both skepticism and no-lose investigations, we must eschew either Closure or epistemic externalism. (shrink)

Metaethicists have recently devoted a great deal of attention to questions about when a fact counts as a reason for or against a particular conclusion, and how such reasons interact. Chapter 9 asks a broader question: When a set of facts counts in favor of some conclusion, is that always because at least one of those facts is a reason for that conclusion? Examples are offered in which a set supports a conclusion without any fact in that set’s being a (...) reason for. The chapter then assesses the significance of such examples for philosophical methodology, the ‘reasons-first’ program, and metanormative realism. (shrink)

Paulin and Cahill‐Lane explore the origins of event processing and event prediction in animal evolution. They propose that the evolutionary benefit of being able to predict and thus to quickly react to anticipated events may have triggered the evolution of the earliest nervous systems.

Disjunctivism about perceptual appearances, as I conceive of it, is a theory which seeks to preserve a naïve realist conception of veridical perception in the light of the challenge from the argument from hallucination. The naïve realist claims that some sensory experiences are relations to mind-independent objects. That is to say, taking experiences to be episodes or events, the naïve realist supposes that some such episodes have as constituents mind-independent objects. In turn, the disjunctivist claims that in a case of (...) veridical perception like this very kind of experience that you now have, the experiential episode you enjoy is of a kind which could not be occurring were you having an hallucination. The common strategy of arguments from hallucination set out to show that certain things are true of hallucinations, and hence must be true of perceptions. For example, it is argued that hallucinations must have non-physical objects of awareness, or that such states are not relations to anything at all, but are at best seeming relations to objects. In insisting that veridical perceptual experience is of a distinct kind from hallucination, the disjunctivist denies that any of these conceptions of hallucination challenges our conception of veridical perceptions as relations to mind-independent objects. More specifically, I assume that the disjunctivist advocates naïve realism because they think that this position best articulates how sensory experience seems to us to be just through reflection. If the disjunctivist is correct in this contention, then anyone who accepts the conclusion of the argument from hallucination must also accept that the nature of sensory experience is other than it seems to us to be. In turn, one may complain that any such error theory is liable to lead to sceptical consequences. A Humean scepticism about the senses launches a challenge about our knowledge of the world through questioning the conception we have of what sense experience is, and how it can provide knowledge of the world. (shrink)

Different people reason differently, which means that sometimes they reach different conclusions from the same evidence. We maintain that this is not only natural, but rational. In this essay we explore the epistemology of that state of affairs. First we will canvass arguments for and against the claim that rational methods of reasoning must always reach the same conclusions from the same evidence. Then we will consider whether the acknowledgment that people have divergent rational reasoning methods should undermine one’s confidence (...) in one’s own reasoning. Finally we will explore how agents who employ distinct yet equally rational methods of reasoning should respond to interactions with the products of each others’ reasoning. We find that the epistemology of multiple reasoning methods has been misunderstood by a number of authors writing on epistemic permissiveness and peer disagreement. (shrink)

Pope John Paul II called for an intense dialogue between science and theology, “a common interactive relationship,” in which each discipline is “open to the discoveries and insights of the other” while retaining its own integrity. This essay seeks to be responsive to that call and is an initial exploration of relationships between contemporary neuroscience and Catholic theological ethics. It examines neuroscientific data on the bicameral brain and theological ethical data on marital ethics, including divorce and remarriage, and asks what (...) insight the former might provide into both the latter and the different ethical methods that respond to marital ethics. The analysis is undertaken in the hope of illuminating a pathway that opens the insights of one way of doing theological ethics to the insights of another way, thereby eliminating the unnecessary, unhelpful, and sometimes un‐Christian polarizations that presently separate them. (shrink)

For the sake of consistency with settled principles from other theological and ethical questions, there is a need for a Christian reexamination of in vitro fertilization (IVF). Both Old and New Testaments demonstrate that human personal life begins at conception or fertilization. Additionally, the Bible teaches that human beings are persons in the image of God from the very beginning of their existence. Thus, it can be concluded that the embryos created via IVF are persons in God’s image. Applying this (...) to the destruction and freezing of embryos, several limitations or restrictions present themselves—embryos should not be purposefully destroyed or wasted, all embryos ought to be implanted, and embryos should not be frozen. Ultimately, however, due to the immense quantity of embryo wastage, it is concluded that Christians should avoid this form of assisted reproductive technology and consider it a pro-life issue. (shrink)

In this chapter, we explore the role of habit in giving shape to conscious experience and importantly to our pre-reflective awareness of ourselves which includes the sense of mineness that accompanies our conscious experience. For the most part, discussions in philosophy of mind and phenomenology concerning pre-reflective self-awareness are focused on determining the relationship between phenomenal consciousness and selfhood. For this reason perhaps, the existence of pre-reflective self-awareness is usually appealed to as evidence for a form of selfhood that appears (...) within conscious experience as a component of its synchronic unity. In this chapter, however, we will concern ourselves with the pre-reflective sense of ourselves that appears in conscious experience as it pertains to the diachronic unity of the self—that is the sense of a unitary self as existing over the course of multiple episodic experiences. Our aim is to provide a phenomenological account of the relationship between the minimal, pre-reflective sense of self and what is often termed the ‘narrative self.’ We will argue that habits play a role in preserving the significance of our past in our present experience and in unifying our experience as a self for whom the world is present across disparate episodes of experience. (shrink)

This study examined the influence of 7 high school esports developmental programs on student self-regulation, growth mindset, positive youth development, perceived general health and physical activity, and sport behaviour. A total of 188 students originally participated, with 58 participants completing both pre- and post-program information. At baseline, no significant differences were found between youth e-athletes and their aged-matched controls. The analysis for the observation period showed a significant interaction effect for the PYD confidence scale, with post-hoc comparisons showing a significant (...) decrease in the control group from pre- to post assessment whereas the esports group remained the same. Time main effects showed a decrease in the self-regulation motivation factor, PYD connection factor and PA for all participants. Overall, this study showed that students enrolled in their respective school esports program did not differ from those who did not in self-regulation, growth mindset, PYD, perceived health and PA, and sport behaviour. It was likely that all participants showed a decrease in motivation, connection, and PA due to COVID19 lockdown during the study period. This study is the first to investigate the longitudinal impact of student involvement in high school esports and showed that esports participation did not have a negative impact on any health or psychological factors. (shrink)

Listening to someone from some distance in a crowded room you may experience the following phenomenon: when looking at them speak, you may both hear and see where the source of the sounds is; but when your eyes are turned elsewhere, you may no longer be able to detect exactly where the voice must be coming from. With your eyes again fixed on the speaker, and the movement of her lips a clear sense of the source of the sound will (...) return. This ‘ventriloquist’ effect reflects the ways in which visual cognition can dominate auditory perception. And this phenomenological observation is one that you can verify or disconfirm in your own case just by the slightest reflection on what it is like for you to listen to someone with or without visual contact with them. (shrink)

What goes wrong, from a rational point of view, when an agent’s beliefs change while her evidence remains constant? I canvass a number of answers to this question suggested by recent literature, then identify some desiderata I would like any potential answer to meet. Finally, I suggest that the rational problem results from the undermining of reasoning processes that are necessarily extended in time.

Book description: The capacity to represent and think about time is one of the most fundamental and least understood aspects of human cognition and consciousness. This book throws new light on central issues in the study of the mind by uniting, for the first time, psychological and philosophical approaches dealing with the connection between temporal representation and memory. Fifteen specially written essays by leading psychologists and philosophers investigate the way in which time is represented in memory, and the role memory (...) plays in our ability to reason about time. They offer insights into current theories of memory processes and of the mechanisms and cognitive abilities underlying temporal judgements, and draw out fundamental issues concerning the phenomenology and epistemology of memory and our understanding of time. The chapters are arranged into four sections, each focused on one area of current research: Keeping Track of Time, and Temporal Representation; Memory, Awareness and the Past; Memory and Experience; Knowledge and the Past: The Epistemology and Metaphysics of Time. A general introduction gives an overview of the topics discussed and makes explicit central themes which unify the different philosophical and psychological approaches. (shrink)

Roger White argued for a principle of indifference. Hart and Titelbaum showed that White’s argument relied on an intuition about conditioning on biconditionals that, while widely shared, is incorrect. Hawthorne, Landes, Wallmann, and Williamson argue for a principle of indifference. Remarkably, their argument relies on the same faulty intuition. We explain their intuition, explain why it’s faulty, and show how it generates their principle of indifference. 1Introduction 2El Caminos and Indifference 2.1Overview 2.2Fins and antennas 2.3HLWW in the example 2.4The restrictiveness (...) of Condition 2 2.5Summary 3The Specifics of HLWW s Argument 3.1Mapping their conditions to our equations 3.2HLWW’s responses to objections. (shrink)

I argue that given standard deontic logic, wide-scope rational requirements entail narrow-scope rational requirements. In particular, the widely-embraced Enkratic Principle entails that if a particular combination of attitudes is rationally forbidden, it is also rationally forbidden to believe that that combination of attitudes is required.

Abstract. Richard Feldman’s Uniqueness Thesis holds that “a body of evidence justifies at most one proposition out of a competing set of proposi- tions”. The opposing position, permissivism, allows distinct rational agents to adopt differing attitudes towards a proposition given the same body of evidence. We assess various motivations that have been offered for Uniqueness, including: concerns about achieving consensus, a strong form of evidentialism, worries about epistemically arbitrary influences on belief, a focus on truth-conduciveness, and consequences for peer disagreement. (...) We argue that each of these motivations either misunderstands the commitments of permissivism or is question-begging. Better understanding permissivism makes it a much more plausible position. (shrink)

Consumers are increasingly facing product evaluation and choice situations that include information about product sustainability, i.e., information about a product’s relative environmental and social impact. In many cases, consumers have to make decisions that involve a trade-off between product sustainability and other valued product attributes. Similarly, product and marketing managers need to make decisions that reflect how consumers will respond to different trade-off scenarios. In the current research, we study consumer responses across two different possible trade-off scenarios: one in which (...) consumers face a trade-off between product sustainability and hedonic value, and another in which they must trade-off between product sustainability and utilitarian value. Our results suggest that, overall, consumers are more likely to trade-off hedonic value for sustainability than to trade-off utilitarian value for sustainability. In Studies 1A and 1B, we presented participants with a product choice task and also measured their anticipatory emotions as they contemplated their options. The results suggest that given a trade-off, consumers are more likely to choose a sustainable product when they have to trade-off hedonic value than when they have to trade-off utilitarian value. Further, these studies provide some insight into the emotions underlying this effect. In Study 2, we use a different consumer response measure, relative purchase likelihood, and investigate the effect of trade-off type across categories that vary in the degree to which hedonic and utilitarian attributes are perceived to be important. Our results suggest that the effect of trade-off type still holds, yet is moderated by product type such that consumers’ greater willingness to trade-off hedonic value for sustainability is attenuated as the relative importance of hedonic attributes increases. In addition to building on our theoretical understanding of decision making given trade-offs with moral attributes, this research is also intended to support managers as they define and choose among various strategic, product development, and marketing promotion options. (shrink)

Ayn Rand's dystopian work, Anthem, has primarily been read as a critical response to the communist collectivism of the Russia of her youth. However, a close consideration of the religious allusions in the text reveals that Rand was responding to religious collectivism as much as to the communist variety. In fact, Rand's personal writings reveal that Anthem's apotheosis of man is a response to religion's denial of self, which Rand viewed as the offense of a collectivist society. In Anthem, Rand (...) emphasizes her opposition to religion through the ironic employment of religious themes and images. (shrink)

Disjunctivism about perceptual appearances, as I conceive of it, is a theory which seeks to preserve a na.

Begins by explaining then proving a generalized language dependence result similar to Goodman's "grue" problem. I then use this result to cast doubt on the existence of an objective evidential favoring relation (such as "the evidence confirms one hypothesis over another," "the evidence provides more reason to believe one hypothesis over the other," "the evidence justifies one hypothesis over the other," etc.). Once we understand what language dependence tells us about evidential favoring, our options are an implausibly strong conception of (...) the a priori, a hard externalism on which agents are unable to determine what their evidence favors, or a subjectivist view that makes evidential favoring relative to features of the agent. (shrink)

Responding to Cappelen and Dever’s claim that there is no distinctive role for perspectivality in epistemology, I argue that facts about the outcomes of one’s own reasoning processes may have a different evidential significance than facts about the outcomes of others’.

The Sleeping Beauty Problem attracts so much attention because it connects to a wide variety of unresolved issues in formal epistemology, decision theory, and the philosophy of science. The problem raises unanswered questions concerning relative frequencies, objective chances, the relation between self-locating and non-self-locating information, the relation between self-location and updating, Dutch Books, accuracy arguments, memory loss, indifference principles, the existence of multiple universes, and many-worlds interpretations of quantum mechanics. After stating the problem, this article surveys its connections to all (...) of these areas. (shrink)

Comparisons, and by that I mean the hunt for essential similarities or at least serious family resemblances, between the ethical views of Western and non-Western thinkers have been a staple of comparative philosophy for quite some time now. Some of these comparisons, such as between the views of Aristotle and Confucius, seem especially apt and revealing. However, I’ve often wondered whether Western “ethical theory”—virtue ethics, deontology, or consequentialism—is always the best lens through which to approach non-Western ethical thought. Particularly when (...) the discussion has turned to Buddhism and Buddhist ethics, theories of this sort at best seem to have an uncertain application. This is not to say that .. (shrink)

Can self-locating beliefs be relevant to non-self-locating claims? Traditional Bayesian modeling techniques have trouble answering this question because their updating rule fails when applied to situations involving contextsensitivity. This essay develops a fully general framework for modeling stories involving context-sensitive claims. The key innovations are a revised conditionalization rule and a principle relating models of the same story with different modeling languages. The essay then applies the modeling framework to the Sleeping Beauty Problem, showing that when Beauty awakens her degree (...) of belief in heads should be one-third. This demonstrates that it can be rational for an agent who gains only self-locating beliefs between two times to alter her degree of belief in a non-self-locating claim. (shrink)

The novel coronavirus disease has become a global pandemic, causing substantial anxiety. One potential factor in the spread of anxiety in response to a pandemic threat is emotion contagion, the finding that emotional experiences can be socially spread through conscious and unconscious pathways. Some individuals are more susceptible to social contagion effects and may be more likely to experience anxiety and other mental health symptoms in response to a pandemic threat. Therefore, we studied the relationship between emotion contagion and mental (...) health symptoms during the COVID-19 pandemic. We administered the Emotion Contagion Scale along with a measure of anxiety in response to COVID-19 and secondary outcome measures of depression, anxiety, stress, and obsessive-compulsive disorder symptoms. These measures were completed by a large student sample in the United States. Data were collected in the months of April and May of 2020 when the fear of COVID-19 was widespread. Results revealed that greater susceptibility to emotion contagion was associated with greater concern about the spread of COVID-19, more depression, anxiety, stress, and OCD symptoms. Consumption of media about COVID-19 also predicted anxiety about COVID-19, though results were not moderated by emotion contagion. However, emotion contagion did moderate the relationship between COVID-19-related media consumption and elevated OCD symptoms. Although limited by a cross-sectional design that precludes causal inferences, the present results highlight the need for study of how illness fears may be transmitted socially during a pandemic. (shrink)

Derrida’s “What is a ‘Relevant’ Translation?”, first delivered at the fifteenth annual Assises de la Traduction Littéraire à Arles in 1998, is an address that appears at first to speak from the outside and with a certain deference to professional translators. Yet, it quickly becomes apparent that Derrida not only counts himself among them but uses the occasion to reflect on his own surprising success as a translator of Hegel. This success has to do first and foremost with the proven (...) “relevance” of his translation of the notoriously untranslatable term Aufhebung as relève [in English: sublation]. Not a little perplexed by this apparent triumph, Derrida takes up the French term again, this time redeploying it in the translation of a crucial line from Shakespeare’s Merchant of Venice. In doing so, he relaunches his engagement with Hegel, asking what energies bound up in the concept of relève might yet be released, what internal resistances silently at work in it might still be mobilized to take it in an entirely new direction. Such an engagement enables him to explore in turn what resistances may be at work in the notion of translation itself. Inhabited by an internal otherness, by a constitutive resistance to itself, translation must be understood from the very first as transference. While translation studies have long been attentive to the transferential dynamics in which individual translators find themselves enmeshed, Derrida’s text views transference in more impersonal terms as the tenacious grip in which certain structures of thought hold us, structures which also inform our understanding of translation. How to work with and against this structural unconscious? To address this question, it is necessary to examine Derrida’s own translational practice and the privilege he accords to the term trouvaille. (shrink)

Following the publication of Pope Francis’ Apostolic Exhortation Amoris Laetitia, four aged Cardinals wrote to him asking him to clarify positions in the Exhortation they charged were causing confusion to the faithful. They even suggested he had changed some Catholic doctrines. This essay answers their questions, arguing that Francis has not changed any Catholic doctrine but has changed, in the sense that he has renewed, Catholic pastoral practice. It also argues that, while not changing any Catholic doctrines, he has reprioritized (...) some of them, especially the doctrines of the authority and inviolability of conscience and what he calls the “irregular situations” of cohabitation, same-sex unions, and divorce and remarriage without annulment. (shrink)

Derrida's essay, ‘Devant la loi’, opens with the citation of an1897 letter from Freud to his friend, Wilhelm Fliess, in which he confides that he has a presentiment he shall soon discover the origin of morality. What interests Derrida is not only the discovery that will indeed soon follow but the temporal structure of presentiment itself. Seeking to give such a vague intimation a more rigorous sense, he theorizes presentiment as a way of ‘precognizing’ something that will never otherwise have (...) been known as such. Through close readings of Kafka, Freud and Kant, Derrida asks how the moral law itself might be thinkable only in the mode of a certain pre-, a mode whose very ‘beforeness’ has to be radically rethought. (shrink)

A plea: If you're going to propose a Bayesian framework for updating self-locating degrees of belief, please read this piece first. I've tried to survey all the extant formalisms, group them by their general approach, then describe challenges faced by every formalism employing a given approach. Hopefully this survey will prevent further instances of authors' re-inventing updating rules already proposed elsewhere in the literature.

Editor’s note: Presidential Address delivered at Portland, Oregon on March 17, 2013 on the occasion of the AOS annual meeting. The submission was not edited, at the insistence of the author; this was granted as a prerogative restricted to his Presidential Address, for reasons that will be understood by a perusing of the subject matter. All infelicities are in keeping with the original submission. Author’s note: In keeping with the theme of this Address the published text aims to reproduce exactly (...) the words that were read out. The version presented here is based on a scanned image of the only copy of the original typescript with the author’s hand-written changes, retrieved from a member of the audience to whom it was given after the proceedings. Transliteration follows the conventions of the Journal, and the source references have been moved into the footnotes. Bibliographical attributions are minimal: colleagues will easily distinguish between sweeping statements which could be documented if need be, and the private opinions of the writer. (shrink)